Research workbench
Crystal structure of trypsin- ovomucoid turkey egg white inhibitor complex
Analyse Crystal structure of trypsin- ovomucoid turkey egg white inhibitor complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1Z7K
- Type
- protein
- Length
- 289 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Trypsin; Ovomucoid
- EC
- 3.4.21.4
- UniProt
- P00761, P68390
- Ligands
- NAG
- Pockets
- 2 · best druggability 0.51
Structure
x-ray diffraction · 3 distinct chains · 12% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Trypsin (EC 3.4.21.4) | protein | 223 | 10% helix, 37% strand | P00761 |
| B | Ovomucoid | protein | 62 | 23% helix, 26% strand | P68390 |
| C | Ovomucoid | protein | 4 | 0% helix, 0% strand | P68390 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 167 | 0.51 | 0.79 | 23 | empty |
| 2 | 168 | 0.48 | 0.77 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 888 Ų buried · 19 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 9 disulfide, 1 glycan (disulfide, N-glycosylation).
Compared structures
- 1Z7K · Crystal Structure of Trypsin- Ovomucoid turkey egg white inhibitor complex · the same entry in another collection · chain A against A, TM-score 1.00
- P00761 · AlphaFold monomer V2.0 prediction for trypsin (P00761) · a predicted model of the same protein · chain A against A, TM-score 0.99
- P68390 · AlphaFold monomer V2.0 prediction for ovomucoid (P68390) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00761
- Every structure of UniProt P68390
- Elsewhere: RCSB PDB 1Z7K · PDBe 1Z7K · UniProt P00761 · UniProt P68390
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