Research workbench
The exportin CSE1 in its cargo-free, cytoplasmic state
Analyse The exportin CSE1 in its cargo-free, cytoplasmic state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1Z3H
- Type
- protein
- Length
- 1,839 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin alpha re-exporter
- UniProt
- P33307
- Ligands
- MG
- Pockets
- 20 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 73% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Importin alpha re-exporter | protein | 925 | 74% helix, 1% strand | P33307 |
| B | Importin alpha re-exporter | protein | 914 | 71% helix, 1% strand | P33307 |
Ligands and binding sites
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 410 | 0.77 | 0.86 | 55 | empty |
| 2 | 371 | 0.76 | 0.86 | 53 | empty |
| 3 | 867 | 0.72 | 0.77 | 67 | empty |
| 4 | 447 | 0.64 | 0.77 | 45 | empty |
| 5 | 417 | 0.63 | 0.77 | 45 | empty |
Interfaces
1 interface between chains.
- A–B · 109 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P33307
- Elsewhere: RCSB PDB 1Z3H · PDBe 1Z3H · UniProt P33307
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