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S. cerevisiae SIR1 orc-interaction domain

Analyse S. cerevisiae SIR1 orc-interaction domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1Z1A
Type: protein
Length: 236 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Regulatory protein SIR1
UniProt: P21691
Pockets: 1 · best druggability 0.31

Structure

x-ray diffraction · 2 distinct chains · 17% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Regulatory protein SIR1	protein	117	17% helix, 35% strand	P21691
B	Regulatory protein SIR1	protein	119	18% helix, 34% strand	P21691

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	54	0.31	0.76	16	empty

Modifications

Observed in the structure: 6 modified (engineered).

Compared structures

1Z1A · S. cerevisiae Sir1 ORC-interaction domain · the same entry in another collection · chain A against A, TM-score 1.00
P21691 · AlphaFold monomer V2.0 prediction for regulatory protein SIR1 (P21691) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P21691
Elsewhere: RCSB PDB 1Z1A · PDBe 1Z1A · UniProt P21691

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