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Solution structure of S5A uim-1/UBIQUITIN complex

Analyse Solution structure of S5A uim-1/UBIQUITIN complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1YX5
Type: protein
Length: 188 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 26S proteasome non-ATPase regulatory subunit 4; Ubiquitin
UniProt: P55036, P62988
Pockets: 1 · best druggability 0.38

Structure

solution nmr · 2 distinct chains · 44% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	26S proteasome non-ATPase regulatory subunit 4	protein	112	58% helix, 0% strand	P55036
B	Ubiquitin	protein	76	22% helix, 34% strand	P62988

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	88	0.38	0.76	16	empty

Interfaces

1 interface between chains.

A–B · 475 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

1YX5 · Solution Structure of S5a UIM-1/Ubiquitin Complex · the same entry in another collection · chain A against A, TM-score 1.00
P55036 · AlphaFold monomer V2.0 prediction for 26S proteasome non-ATPase regulatory subunit 4… · a predicted model of the same protein · chain A against A, TM-score 0.38

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P55036
Every structure of UniProt P62988
Elsewhere: RCSB PDB 1YX5 · PDBe 1YX5 · UniProt P55036 · UniProt P62988

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