Research workbench
Hepatitis C virus NS5B RNA-dependent RNA polymerase genotype 2A
Analyse Hepatitis C virus NS5B RNA-dependent RNA polymerase genotype 2A in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1YV2
- Type
- protein
- Length
- 548 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA dependent RNA polymerase
- UniProt
- P26660
- Ligands
- SO4
- Pockets
- 6 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 48% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA dependent RNA polymerase | protein | 548 | 48% helix, 15% strand | P26660 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 387 | 0.67 | 0.80 | 48 | empty |
| 2 | 173 | 0.55 | 0.80 | 27 | empty |
| 3 | 176 | 0.55 | 0.80 | 29 | SO4 |
| 4 | 198 | 0.51 | 0.77 | 36 | empty |
| 5 | 141 | 0.44 | 0.76 | 26 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 1YV2 · Hepatitis C virus NS5B RNA-dependent RNA Polymerase genotype 2a · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P26660
- Elsewhere: RCSB PDB 1YV2 · PDBe 1YV2 · UniProt P26660
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