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Structure of TNF receptor associated factor 2 (TRAF2)

Analyse Structure of TNF receptor associated factor 2 (TRAF2) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1CA4
Type: protein
Length: 1,008 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (TNF receptor associated factor 2)
UniProt: Q12933
Pockets: 8 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 18% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F	Protein (TNF receptor associated factor 2)	protein	168	18% helix, 33% strand	Q12933

Pockets

8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1043	0.74	0.77	83	empty
2	1095	0.74	0.77	89	empty
3	111	0.37	0.74	24	empty
4	112	0.36	0.73	23	empty
5	119	0.36	0.73	22	empty

Interfaces

6 interfaces between chains.

D–E · 580 Å² buried · 4 hydrogen bonds · protein-protein
A–B · 568 Å² buried · 6 hydrogen bonds · protein-protein
E–F · 567 Å² buried · 4 hydrogen bonds · protein-protein
B–C · 565 Å² buried · 5 hydrogen bonds · protein-protein
D–F · 561 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

1CA4 · Structure of TNF receptor associated factor 2 (TRAF2) · the same entry in another collection · chain C against C, TM-score 1.00
Q12933 · AlphaFold monomer V2.0 prediction for TNF receptor-associated factor 2 (Q12933) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q12933
Elsewhere: RCSB PDB 1CA4 · PDBe 1CA4 · UniProt Q12933

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