Research workbench

Triosephosphate isomerase (tim)

Analyse Triosephosphate isomerase (tim) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1YDV
Type: protein
Length: 492 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Triosephosphate isomerase
EC: 5.3.1.1
UniProt: Q07412
Pockets: 3 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Triosephosphate isomerase (EC 5.3.1.1)	protein	246	42% helix, 15% strand	Q07412

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	241	0.77	0.91	42	empty
2	84	0.43	0.79	17	empty
3	88	0.41	0.78	17	empty

Interfaces

1 interface between chains.

A–B · 1747 Å² buried · 29 hydrogen bonds · protein-protein

Compared structures

1YDV · Triosephosphate isomerase (tim) · the same entry in another collection · chain A against A, TM-score 1.00
Q07412 · AlphaFold monomer V2.0 prediction for triosephosphate isomerase (Q07412) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q07412
Elsewhere: RCSB PDB 1YDV · PDBe 1YDV · UniProt Q07412

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