Research workbench

CABAN33- Y37V/E44G/R45L triple mutant

Analyse CABAN33- Y37V/E44G/R45L triple mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1YC8
Type: protein
Length: 228 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Anti-vsg immunoglobulin heavy chain variable domain CABAN33
Pockets: 2 · best druggability 0.49

Structure

x-ray diffraction · 2 distinct chains · 3% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Anti-vsg immunoglobulin heavy chain variable domain CABAN33	protein	116	3% helix, 48% strand	—
B	Anti-vsg immunoglobulin heavy chain variable domain CABAN33	protein	112	3% helix, 54% strand	—

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	181	0.49	0.77	27	empty
2	71	0.43	0.81	21	empty

Interfaces

1 interface between chains.

A–B · 711 Å² buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1YC8 · cAbAn33- Y37V/E44G/R45L triple mutant · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 1YC8 · PDBe 1YC8

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