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Structure of teni from bacillus subtilis

Analyse Structure of teni from bacillus subtilis in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1YAD
Type: protein
Length: 763 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Regulatory protein teni
UniProt: P25053
Ligands: SO4
Pockets: 3 · best druggability 0.70

Structure

x-ray diffraction · 2 distinct chains · 46% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C, D	Regulatory protein teni	protein	190	47% helix, 19% strand	P25053
B	Regulatory protein teni	protein	193	46% helix, 19% strand	P25053

Ligands and binding sites

SO4 · Sulfate ion · ion · 8 copies · chains A, B, C, D
144 · Tris-hydroxymethyl-methyl-ammonium · additive · 3 copies · chains A, B, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	503	0.70	0.80	74	SO4, 144
2	490	0.69	0.80	73	SO4, 144
3	115	0.45	0.78	20	empty

Interfaces

4 interfaces between chains.

A–B · 799 Å² buried · 7 hydrogen bonds · protein-protein
C–D · 794 Å² buried · 10 hydrogen bonds · protein-protein
A–D · 407 Å² buried · 6 hydrogen bonds · protein-protein
B–D · 215 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

1YAD · Structure of TenI from Bacillus subtilis · the same entry in another collection · chain A against A, TM-score 1.00
P25053 · AlphaFold monomer V2.0 prediction for thiazole tautomerase (P25053) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P25053
Elsewhere: RCSB PDB 1YAD · PDBe 1YAD · UniProt P25053

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