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Crystal structure of the titin domains Z1Z2 in complex with telethonin

Analyse Crystal structure of the titin domains Z1Z2 in complex with telethonin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1YA5
Type: protein
Length: 484 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: N2B-titin isoform; Telethonin
UniProt: Q6PJP0, O15273
Ligands: SO4
Pockets: 5 · best druggability 0.60

Structure

x-ray diffraction · 3 distinct chains · 3% helix, 61% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	N2B-titin isoform	protein	198	3% helix, 62% strand	Q6PJP0
B	N2B-titin isoform	protein	197	3% helix, 59% strand	Q6PJP0
T	Telethonin	protein	89	3% helix, 63% strand	O15273

Ligands and binding sites

SO4 · Sulfate ion · ion · 5 copies · chains A, B, T

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	322	0.60	0.78	42	SO4
2	174	0.57	0.81	33	empty
3	157	0.47	0.76	24	empty
4	107	0.43	0.78	19	empty
5	112	0.40	0.75	20	empty

Interfaces

3 interfaces between chains.

B–T · 1991 Å² buried · 41 hydrogen bonds · protein-protein
A–T · 1660 Å² buried · 46 hydrogen bonds · protein-protein
A–B · 64 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

1YA5 · Crystal structure of the titin domains z1z2 in complex with telethonin · the same entry in another collection · chain A against A, TM-score 1.00
O15273 · AlphaFold monomer V2.0 prediction for telethonin (O15273) · a predicted model of the same protein · chain T against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6PJP0
Every structure of UniProt O15273
Elsewhere: RCSB PDB 1YA5 · PDBe 1YA5 · UniProt Q6PJP0 · UniProt O15273

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