Research workbench
Structural basis for recruitment of UBC12 by an E2-binding domain in NEDD8'S E1
Analyse Structural basis for recruitment of UBC12 by an E2-binding domain in NEDD8'S E1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1Y8X
- Type
- protein
- Length
- 252 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ubiquitin-conjugating enzyme E2 M; Ubiquitin-activating enzyme E1C
- EC
- 6.3.2.19
- UniProt
- P61081, Q8TBC4
Structure
x-ray diffraction · 2 distinct chains · 29% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ubiquitin-conjugating enzyme E2 M (EC 6.3.2.19) | protein | 160 | 30% helix, 20% strand | P61081 |
| B | Ubiquitin-activating enzyme E1C | protein | 92 | 27% helix, 29% strand | Q8TBC4 |
Interfaces
1 interface between chains.
- A–B · 925 Ų buried · 22 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 modified (engineered).
Compared structures
- 1Y8X · Structural basis for recruitment of Ubc12 by an E2-binding domain in NEDD8's E1 · the same entry in another collection · chain A against A, TM-score 1.00
- P61081 · AlphaFold monomer V2.0 prediction for NEDD8-conjugating enzyme UBC12 (P61081) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q8TBC4 · AlphaFold monomer V2.0 prediction for NEDD8-activating enzyme E1 catalytic subunit… · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P61081
- Every structure of UniProt Q8TBC4
- Elsewhere: RCSB PDB 1Y8X · PDBe 1Y8X · UniProt P61081 · UniProt Q8TBC4
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