Research workbench
Solution structure of PATJ/PALS1 L27 domain complex
Analyse Solution structure of PATJ/PALS1 L27 domain complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1Y76
- Type
- protein
- Length
- 244 residues
- Chains
- 4
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein associated to tight junctions; Maguk P55 subfamily member 5
- UniProt
- O55164, Q8N3R9
- Pockets
- 2 · best druggability 0.58
Structure
solution nmr · 2 distinct chains · 83% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Protein associated to tight junctions | protein | 62 | 85% helix, 0% strand | O55164 |
| B, D | Maguk P55 subfamily member 5 | protein | 60 | 80% helix, 0% strand | Q8N3R9 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 138 | 0.58 | 0.83 | 17 | empty |
| 2 | 124 | 0.54 | 0.82 | 18 | empty |
Interfaces
6 interfaces between chains.
- A–D · 1271 Ų buried · 14 hydrogen bonds · protein-protein
- B–C · 1225 Ų buried · 18 hydrogen bonds · protein-protein
- B–D · 379 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 314 Ų buried · 0 hydrogen bonds · protein-protein
- A–B · 269 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 1Y76 · Solution Structure of Patj/Pals1 L27 Domain Complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q8N3R9 · AlphaFold monomer V2.0 prediction for maguk P55 subfamily member 5 (Q8N3R9) · a predicted model of the same protein · chain B against A, TM-score 0.79
- O55164 · AlphaFold monomer V2.0 prediction for multiple PDZ domain protein (O55164) · a predicted model of the same protein · chain A against A, TM-score 0.65
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O55164
- Every structure of UniProt Q8N3R9
- Elsewhere: RCSB PDB 1Y76 · PDBe 1Y76 · UniProt O55164 · UniProt Q8N3R9
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