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Crystal structure of a novel germination protease from spores of bacillus megaterium: structural rearrangements and zymogen activation

Analyse Crystal structure of a novel germination protease from spores of bacillus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1C8B
Type: protein
Length: 640 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Spore protease
EC: 3.4.99.-
UniProt: P22321
Pockets: 9 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Spore protease (EC 3.4.99.-)	protein	320	30% helix, 19% strand	P22321

Pockets

9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	739	0.73	0.79	68	empty
2	534	0.71	0.80	71	empty
3	522	0.69	0.79	73	empty
4	226	0.56	0.79	38	empty
5	228	0.55	0.78	37	empty

Interfaces

1 interface between chains.

A–B · 1241 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

1C8B · Crystal structure of a novel germination protease from spores of bacillus megaterium… · the same entry in another collection · chain A against A, TM-score 1.00
P22321 · AlphaFold monomer V2.0 prediction for germination protease (P22321) · a predicted model of the same protein · chain A against A, TM-score 0.85

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22321
Elsewhere: RCSB PDB 1C8B · PDBe 1C8B · UniProt P22321

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