Research workbench

Human ubiquitin conjugating enzyme E2E2

Analyse Human ubiquitin conjugating enzyme E2E2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1Y6L
Type: protein
Length: 444 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ubiquitin-conjugating enzyme E2E2
EC: 6.3.2.19
UniProt: Q96LR5
Pockets: 3 · best druggability 0.45

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Ubiquitin-conjugating enzyme E2E2 (EC 6.3.2.19)	protein	148	37% helix, 18% strand	Q96LR5

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	56	0.45	0.85	18	empty
2	116	0.36	0.73	22	empty
3	53	0.28	0.75	15	empty

Interfaces

2 interfaces between chains.

A–B · 288 Å² buried · 1 hydrogen bond · protein-protein
A–C · 226 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

1Y6L · Human ubiquitin conjugating enzyme E2E2 · the same entry in another collection · chain A against A, TM-score 1.00
Q96LR5 · AlphaFold monomer V2.0 prediction for ubiquitin-conjugating enzyme E2 E2 (Q96LR5) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96LR5
Elsewhere: RCSB PDB 1Y6L · PDBe 1Y6L · UniProt Q96LR5

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