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X-ray crystal structure of mycobacterium tuberculosis pyridoxine 5'-phosphate oxidase at 1.8 a resolution

Analyse X-ray crystal structure of mycobacterium tuberculosis pyridoxine 5'-phosphate… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1XXO
Type: protein
Length: 286 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hypothetical protein RV1155
UniProt: O06553
Pockets: 3 · best druggability 0.60

Structure

x-ray diffraction · 1 distinct chain · 27% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Hypothetical protein RV1155	protein	143	27% helix, 38% strand	O06553

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	331	0.60	0.77	36	empty
2	184	0.48	0.75	28	empty
3	73	0.43	0.81	22	empty

Interfaces

1 interface between chains.

A–B · 1278 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

1XXO · X-ray crystal structure of mycobacterium tuberculosis pyridoxine 5'-phosphate oxidase at… · the same entry in another collection · chain A against A, TM-score 1.00
O06553 · AlphaFold monomer V2.0 prediction for F420H(2)-dependent reductase RV1155 (O06553) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O06553
Elsewhere: RCSB PDB 1XXO · PDBe 1XXO · UniProt O06553

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