Research workbench
Crystal structure of ureidoglycolate hydrolase from E.COLI. northeast structural genomics consortium target ET81.
Analyse Crystal structure of ureidoglycolate hydrolase from E.COLI. northeast… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1XSQ
- Type
- protein
- Length
- 309 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ureidoglycolate hydrolase
- EC
- 3.5.3.19
- UniProt
- P77731
- Pockets
- 3 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 4% helix, 54% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ureidoglycolate hydrolase (EC 3.5.3.19) | protein | 154 | 3% helix, 55% strand | P77731 |
| B | Ureidoglycolate hydrolase (EC 3.5.3.19) | protein | 155 | 5% helix, 52% strand | P77731 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 152 | 0.53 | 0.80 | 21 | empty |
| 2 | 148 | 0.51 | 0.80 | 19 | empty |
| 3 | 70 | 0.34 | 0.76 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1634 Ų buried · 25 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (engineered).
Compared structures
- 1XSQ · Crystal structure of ureidoglycolate hydrolase from E.coli. Northeast Structural Genomics… · the same entry in another collection · chain A against A, TM-score 1.00
- P77731 · AlphaFold monomer V2.0 prediction for ureidoglycolate lyase (P77731) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P77731
- Elsewhere: RCSB PDB 1XSQ · PDBe 1XSQ · UniProt P77731
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.