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Crystal structure of the HSPBP1 core domain

Analyse Crystal structure of the HSPBP1 core domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1XQR
Type: protein
Length: 536 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: HSPBP1 protein
UniProt: Q9NZL4
Pockets: 3 · best druggability 0.65

Structure

x-ray diffraction · 1 distinct chain · 79% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	HSPBP1 protein	protein	268	79% helix, 0% strand	Q9NZL4

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	313	0.65	0.81	43	empty
2	305	0.65	0.81	37	empty
3	375	0.64	0.78	39	empty

Interfaces

1 interface between chains.

A–B · 834 Å² buried · 5 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 18 modified (engineered).

Compared structures

1XQR · Crystal structure of the HspBP1 core domain · the same entry in another collection · chain A against A, TM-score 1.00
Q9NZL4 · AlphaFold monomer V2.0 prediction for HSP70-binding protein 1 (Q9NZL4) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NZL4
Elsewhere: RCSB PDB 1XQR · PDBe 1XQR · UniProt Q9NZL4

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