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Crystal structure of cyclophilin from trypanosoma cruzi
Analyse Crystal structure of cyclophilin from trypanosoma cruzi in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1XO7
- Type
- protein
- Length
- 664 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cyclophilin
- UniProt
- Q4DPB9
- Pockets
- 5 · best druggability 0.62
Structure
x-ray diffraction · 1 distinct chain · 16% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Cyclophilin | protein | 166 | 16% helix, 35% strand | Q4DPB9 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 251 | 0.62 | 0.81 | 44 | empty |
| 2 | 94 | 0.42 | 0.78 | 26 | empty |
| 3 | 113 | 0.37 | 0.74 | 22 | empty |
| 4 | 79 | 0.37 | 0.77 | 23 | empty |
| 5 | 75 | 0.35 | 0.76 | 20 | empty |
Interfaces
2 interfaces between chains.
- B–C · 659 Ų buried · 7 hydrogen bonds · protein-protein
- B–D · 319 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 1XO7 · Crystal structure of cyclophilin from Trypanosoma cruzi · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q4DPB9
- Elsewhere: RCSB PDB 1XO7 · PDBe 1XO7 · UniProt Q4DPB9
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