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Crystal structure of plasmodium falciparum antioxidant protein (1-cys peroxiredoxin)

Analyse Crystal structure of plasmodium falciparum antioxidant protein (1-cys… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1XIY
Type: protein
Length: 350 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Peroxiredoxin
UniProt: Q5MYR6
Pockets: 4 · best druggability 0.58

Structure

x-ray diffraction · 2 distinct chains · 31% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Peroxiredoxin	protein	172	32% helix, 27% strand	Q5MYR6
B	Peroxiredoxin	protein	178	30% helix, 26% strand	Q5MYR6

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	163	0.58	0.82	22	empty
2	110	0.53	0.82	23	empty
3	203	0.50	0.76	28	empty
4	78	0.43	0.80	16	empty

Interfaces

1 interface between chains.

A–B · 924 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (oxidation).

Compared structures

1XIY · Crystal Structure of Plasmodium falciparum antioxidant protein (1-Cys peroxiredoxin) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5MYR6
Elsewhere: RCSB PDB 1XIY · PDBe 1XIY · UniProt Q5MYR6

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