Research workbench
Complex HCV core-Fab 19D9D6-protein L mutant (D55A, L57H, Y64W) in space group P21212
Analyse Complex HCV core-Fab 19D9D6-protein L mutant (D55A, L57H, Y64W) in space group… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1XCT
- Type
- protein
- Length
- 1,069 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Capsid protein C; Monoclonal antibody 19D9D6 light chain; Monoclonal antibody 19D9D6…
- UniProt
- P26661
- Pockets
- 10 · best druggability 0.72
Structure
x-ray diffraction · 6 distinct chains · 11% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| P | Capsid protein C | protein | 30 | 10% helix, 0% strand | P26661 |
| Q | Capsid protein C | protein | 22 | 0% helix, 0% strand | P26661 |
| A, C | Monoclonal antibody 19D9D6 light chain | protein | 220 | 8% helix, 52% strand | — |
| B, D | Monoclonal antibody 19D9D6 heavy chain | protein | 218 | 7% helix, 48% strand | — |
| L | Protein L | protein | 70 | 27% helix, 39% strand | — |
| M | Protein L | protein | 71 | 18% helix, 37% strand | — |
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 774 | 0.72 | 0.78 | 67 | empty |
| 2 | 363 | 0.62 | 0.78 | 51 | empty |
| 3 | 498 | 0.59 | 0.74 | 70 | empty |
| 4 | 226 | 0.56 | 0.78 | 34 | empty |
| 5 | 252 | 0.52 | 0.76 | 36 | empty |
Interfaces
10 interfaces between chains.
- C–D · 1885 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 1775 Ų buried · 13 hydrogen bonds · protein-protein
- C–M · 709 Ų buried · 13 hydrogen bonds · protein-protein
- L–M · 674 Ų buried · 6 hydrogen bonds · protein-protein
- P–B · 611 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 1XCT · Complex HCV core-Fab 19D9D6-Protein L mutant (D55A, L57H, Y64W) in space group P21212 · the same entry in another collection · chain P against P, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P26661
- Elsewhere: RCSB PDB 1XCT · PDBe 1XCT · UniProt P26661
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