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The crystal structure of the Fab fragment of a rat monoclonal antibody against the main immunogenic region of the human muscle acetylcholine receptor
Analyse The crystal structure of the Fab fragment of a rat monoclonal antibody against… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1C5D
- Type
- protein
- Length
- 855 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Monoclonal antibody against the main immunogenic region of the human muscle acetylcholine…
- Pockets
- 8 · best druggability 0.72
Structure
x-ray diffraction · 3 distinct chains · 5% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L, A | Monoclonal antibody against the main immunogenic region of the human muscle acetylcholine receptor | protein | 213 | 6% helix, 50% strand | — |
| H | Monoclonal antibody against the main immunogenic region of the human muscle acetylcholine receptor | protein | 214 | 6% helix, 46% strand | — |
| B | Monoclonal antibody against the main immunogenic region of the human muscle acetylcholine receptor | protein | 215 | 3% helix, 47% strand | — |
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 941 | 0.72 | 0.77 | 95 | empty |
| 2 | 731 | 0.69 | 0.77 | 63 | empty |
| 3 | 663 | 0.66 | 0.75 | 61 | empty |
| 4 | 79 | 0.40 | 0.79 | 23 | empty |
| 5 | 98 | 0.37 | 0.75 | 20 | empty |
Interfaces
5 interfaces between chains.
- A–B · 1911 Ų buried · 20 hydrogen bonds · protein-protein
- L–H · 1862 Ų buried · 21 hydrogen bonds · protein-protein
- L–A · 214 Ų buried · 0 hydrogen bonds · protein-protein
- L–B · 185 Ų buried · 0 hydrogen bonds · protein-protein
- H–B · 124 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
- 1C5D · The crystal structure of the Fab fragment of a rat monoclonal antibody against the main… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 1C5D · PDBe 1C5D
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