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HSP40-YDJ1 dimerization domain

Analyse HSP40-YDJ1 dimerization domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1XAO
Type: protein
Length: 230 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mitochondrial protein import protein MAS5
UniProt: P25491
Pockets: 2 · best druggability 0.34

Structure

x-ray diffraction · 1 distinct chain · 14% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Mitochondrial protein import protein MAS5	protein	115	14% helix, 37% strand	P25491

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	68	0.34	0.76	14	empty
2	59	0.33	0.76	15	empty

Interfaces

1 interface between chains.

A–B · 3302 Å² buried · 27 hydrogen bonds · protein-protein

Compared structures

1XAO · Hsp40-Ydj1 dimerization domain · the same entry in another collection · chain A against A, TM-score 1.00
P25491 · AlphaFold monomer V2.0 prediction for mitochondrial protein import protein MAS5 (P25491) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P25491
Elsewhere: RCSB PDB 1XAO · PDBe 1XAO · UniProt P25491

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