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Chimera isopropylmalate dehydrogenase between bacillus subtilis (M) and thermus thermophilus (T) from N-terminal: 20% T middle 20% M residual 60% T, mutated at S82R. low temperature (100K) structure.

Analyse Chimera isopropylmalate dehydrogenase between bacillus subtilis (M) and thermus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1XAC
Type: protein
Length: 345 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 3-isopropylmalate dehydrogenase 2T2M6T S82R
EC: 1.1.1.85
UniProt: P00351
Pockets: 4 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 47% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	3-isopropylmalate dehydrogenase 2T2M6T S82R (EC 1.1.1.85)	protein	345	47% helix, 19% strand	P00351

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	125	0.68	0.89	26	empty
2	52	0.50	0.87	15	empty
3	178	0.47	0.76	26	empty
4	54	0.26	0.73	11	empty

Compared structures

1XAC · Chimera isopropylmalate dehydrogenase between bacillus subtilis (M) and thermus… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00351
Elsewhere: RCSB PDB 1XAC · PDBe 1XAC · UniProt P00351

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