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Crystal structure of endophilin bar domain (mutant)

Analyse Crystal structure of endophilin bar domain (mutant) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1X04
Type: protein
Length: 200 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SH3-containing GRB2-like protein 2
EC: 2.3.1.-
UniProt: Q99962
Pockets: 2 · best druggability 0.36

Structure

x-ray diffraction · 1 distinct chain · 89% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SH3-containing GRB2-like protein 2 (EC 2.3.1.-)	protein	200	89% helix, 0% strand	Q99962

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	73	0.36	0.76	13	empty
2	53	0.30	0.76	11	empty

Modifications

Observed in the structure: 7 modified (engineered).

Compared structures

1X04 · Crystal structure of endophilin BAR domain (mutant) · the same entry in another collection · chain A against A, TM-score 1.00
Q99962 · AlphaFold monomer V2.0 prediction for endophilin-A1 (Q99962) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99962
Elsewhere: RCSB PDB 1X04 · PDBe 1X04 · UniProt Q99962

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