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Crystal structure of the mppn domain of mouse NUP35

Analyse Crystal structure of the mppn domain of mouse NUP35 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1WWH
Type: protein
Length: 319 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nucleoporin 35
UniProt: Q9D7J2
Pockets: 3 · best druggability 0.37

Structure

x-ray diffraction · 3 distinct chains · 32% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nucleoporin 35	protein	81	35% helix, 31% strand	Q9D7J2
B, C	Nucleoporin 35	protein	79	25% helix, 28% strand	Q9D7J2
D	Nucleoporin 35	protein	80	36% helix, 34% strand	Q9D7J2

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	76	0.37	0.77	24	empty
2	84	0.37	0.76	25	empty
3	62	0.33	0.76	19	empty

Interfaces

3 interfaces between chains.

C–D · 603 Å² buried · 9 hydrogen bonds · protein-protein
A–B · 594 Å² buried · 10 hydrogen bonds · protein-protein
B–D · 369 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

1WWH · Crystal structure of the MPPN domain of mouse Nup35 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9D7J2
Elsewhere: RCSB PDB 1WWH · PDBe 1WWH · UniProt Q9D7J2

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