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Crystal structure of a crisp family ca-channel blocker derived from snake venom

Analyse Crystal structure of a crisp family ca-channel blocker derived from snake venom in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1WVR
Type: protein
Length: 221 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Triflin
UniProt: Q8JI39
Ligands: CD
Pockets: 1 · best druggability 0.43

Structure

x-ray diffraction · 1 distinct chain · 33% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Triflin	protein	221	33% helix, 19% strand	Q8JI39

Ligands and binding sites

CD · Cadmium ion · metal · 9 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	151	0.43	0.75	28	empty

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

1WVR · Crystal Structure of a CRISP family Ca-channel blocker derived from snake venom · the same entry in another collection · chain A against A, TM-score 1.00
Q8JI39 · AlphaFold monomer V2.0 prediction for cysteine-rich venom protein triflin (Q8JI39) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8JI39
Elsewhere: RCSB PDB 1WVR · PDBe 1WVR · UniProt Q8JI39

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