Research workbench

NMR study of apo TRP repressor

Analyse NMR study of apo TRP repressor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1WRT
Type: protein
Length: 208 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Apo TRP repressor
UniProt: P0A881
Pockets: 6 · best druggability 0.82

Structure

solution nmr · 1 distinct chain · 51% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
R, S	Apo TRP repressor	protein	104	51% helix, 0% strand	P0A881

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	250	0.82	0.94	41	empty
2	269	0.60	0.79	33	empty
3	172	0.51	0.78	30	empty
4	71	0.44	0.81	15	empty
5	84	0.34	0.74	14	empty

Interfaces

1 interface between chains.

R–S · 1945 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

1WRT · NMR study of apo TRP repressor · the same entry in another collection · chain R against R, TM-score 1.00
P0A881 · AlphaFold monomer V2.0 prediction for TRP operon repressor (P0A881) · a predicted model of the same protein · chain R against A, TM-score 0.56

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0A881
Elsewhere: RCSB PDB 1WRT · PDBe 1WRT · UniProt P0A881

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