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Urate oxidase from aspergillus flavus complexed with 5-amino 6-nitro uracil

Analyse Urate oxidase from aspergillus flavus complexed with 5-amino 6-nitro uracil in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1WRR
Type: protein
Length: 295 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Uricase
EC: 1.7.3.3
UniProt: Q00511
Ligands: UNC
Pockets: 2 · best druggability 0.56

Structure

x-ray diffraction · 1 distinct chain · 28% helix, 39% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Uricase (EC 1.7.3.3)	protein	295	28% helix, 39% strand	Q00511

Ligands and binding sites

UNC · 5-amino-6-nitropyrimidine-2,4(1H,3H)-dione · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	210	0.56	0.79	21	empty
2	179	0.46	0.75	23	UNC

Modifications

Observed in the structure: 1 modified (acetylation).

Compared structures

1WRR · Urate oxidase from aspergillus flavus complexed with 5-amino 6-nitro uracil · the same entry in another collection · chain A against A, TM-score 1.00
Q00511 · AlphaFold monomer V2.0 prediction for uricase (Q00511) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q00511
Elsewhere: RCSB PDB 1WRR · PDBe 1WRR · UniProt Q00511

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