Research workbench
Metal ion dependency of the antiterminator protein, hutp, for binding to the terminator region of hut mRNA- a structural basis
Analyse Metal ion dependency of the antiterminator protein, hutp, for binding to the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1WRO
- Type
- protein
- Length
- 441 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hut operon positive regulatory protein
- UniProt
- P10943
- Ligands
- HIS, BA
- Pockets
- 6 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Hut operon positive regulatory protein | protein | 147 | 39% helix, 30% strand | P10943 |
Ligands and binding sites
- HIS · Histidine · ligand · 3 copies · chains A, C, B
- BA · Barium ion · metal · 6 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 87 | 0.66 | 0.91 | 22 | BA, HIS |
| 2 | 84 | 0.63 | 0.90 | 20 | HIS |
| 3 | 76 | 0.62 | 0.90 | 22 | HIS |
| 4 | 166 | 0.49 | 0.77 | 28 | empty |
| 5 | 56 | 0.34 | 0.78 | 12 | empty |
Interfaces
3 interfaces between chains.
- B–C · 556 Ų buried · 3 hydrogen bonds · protein-protein
- A–B · 554 Ų buried · 3 hydrogen bonds · protein-protein
- A–C · 543 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 1WRO · Metal Ion dependency of the antiterminator protein, HutP, for binding to the terminator… · the same entry in another collection · chain A against A, TM-score 1.00
- P10943 · AlphaFold monomer V2.0 prediction for hut operon positive regulatory protein (P10943) · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10943
- Elsewhere: RCSB PDB 1WRO · PDBe 1WRO · UniProt P10943
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