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Solution structure of APETX1, a specific peptide inhibitor of human ether-a-go-go-related gene potassium channels from the venom of the sea anemone anthopleura elegantissima: a new fold for an herg toxin

Analyse Solution structure of APETX1, a specific peptide inhibitor of human… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
1WQK
Type
protein
Length
42 residues
Chains
1
Method
solution nmr
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Toxin APETX1
UniProt
P61541

Structure

solution nmr · 1 distinct chain · 0% helix, 50% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AToxin APETX1protein420% helix, 50% strandP61541

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

  • 1WQK · Solution structure of APETx1, a specific peptide inhibitor of human Ether-a-go-go-related… · the same entry in another collection · chain A against A, TM-score 1.00
  • P61541 · AlphaFold monomer V2.0 prediction for kappa-actitoxin-AEL2A (P61541) · a predicted model of the same protein · chain A against A, TM-score 0.84

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