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Crystal structure of activated binary complex of hutp, an RNA binding anti-termination protein

Analyse Crystal structure of activated binary complex of hutp, an RNA binding… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1WPV
Type: protein
Length: 441 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hut operon positive regulatory protein
UniProt: P10943
Ligands: HIS, MG
Pockets: 4 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Hut operon positive regulatory protein	protein	147	37% helix, 30% strand	P10943

Ligands and binding sites

HIS · Histidine · ligand · 3 copies · chains A, C, B
MG · Magnesium ion · metal · 3 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	75	0.69	0.94	21	HIS
2	74	0.68	0.94	21	HIS
3	73	0.64	0.92	20	HIS
4	149	0.47	0.77	28	empty

Interfaces

3 interfaces between chains.

A–B · 568 Å² buried · 4 hydrogen bonds · protein-protein
B–C · 565 Å² buried · 4 hydrogen bonds · protein-protein
A–C · 558 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

1WPV · Crystal Structure of Activated Binary complex of HutP, an RNA binding anti-termination… · the same entry in another collection · chain A against A, TM-score 1.00
P10943 · AlphaFold monomer V2.0 prediction for hut operon positive regulatory protein (P10943) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10943
Elsewhere: RCSB PDB 1WPV · PDBe 1WPV · UniProt P10943

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