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Crystal structure of the C-terminal domain of DNA topoisomerase IV

Analyse Crystal structure of the C-terminal domain of DNA topoisomerase IV in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1WP5
Type: protein
Length: 323 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Topoisomerase IV
EC: 5.99.1.-
Pockets: 1 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 13% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Topoisomerase IV (EC 5.99.1.-)	protein	323	13% helix, 40% strand	—

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	843	0.72	0.77	63	empty

Modifications

Observed in the structure: 8 modified (engineered).

Compared structures

1WP5 · Crystal structure of the C-terminal domain of DNA topoisomerase IV · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 1WP5 · PDBe 1WP5

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