Research workbench
Crystal structure of topaquinone-containing amine oxidase activated by cobalt ion
Analyse Crystal structure of topaquinone-containing amine oxidase activated by cobalt… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1WMN
- Type
- protein
- Length
- 1,240 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phenylethylamine oxidase
- EC
- 1.4.3.6
- UniProt
- P46881
- Ligands
- CO
- Pockets
- 15 · best druggability 0.90
Structure
x-ray diffraction · 1 distinct chain · 11% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Phenylethylamine oxidase (EC 1.4.3.6) | protein | 620 | 11% helix, 43% strand | P46881 |
Ligands and binding sites
- CO · Cobalt (II) ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
15 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1073 | 0.90 | 0.92 | 142 | empty |
| 2 | 328 | 0.72 | 0.85 | 52 | empty |
| 3 | 299 | 0.71 | 0.85 | 52 | empty |
| 4 | 222 | 0.67 | 0.84 | 28 | empty |
| 5 | 310 | 0.64 | 0.80 | 36 | empty |
Interfaces
1 interface between chains.
- A–B · 6786 Ų buried · 108 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide, 2 modified (disulfide, nonstandard).
Compared structures
- 1WMN · Crystal structure of topaqui -containing amine oxidase activated by cobalt ion · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P46881
- Elsewhere: RCSB PDB 1WMN · PDBe 1WMN · UniProt P46881
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.