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Crystal structure of the N-terminal tpr domain (1-203) of P67PHOX

Analyse Crystal structure of the N-terminal tpr domain (1-203) of P67PHOX in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1WM5
Type: protein
Length: 205 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Neutrophil cytosol factor 2
UniProt: P19878
Ligands: SO4
Pockets: 2 · best druggability 0.51

Structure

x-ray diffraction · 1 distinct chain · 62% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Neutrophil cytosol factor 2	protein	205	62% helix, 3% strand	P19878

Ligands and binding sites

SO4 · Sulfate ion · ion · 6 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	89	0.51	0.83	18	empty
2	58	0.37	0.79	10	empty

Compared structures

1WM5 · Crystal structure of the N-terminal TPR domain (1-203) of p67phox · the same entry in another collection · chain A against A, TM-score 1.00
P19878 · AlphaFold monomer V2.0 prediction for neutrophil cytosol factor 2 (P19878) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P19878
Elsewhere: RCSB PDB 1WM5 · PDBe 1WM5 · UniProt P19878

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