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Crystal structure of octaprenyl pyrophosphate synthase from hyperthermophilic thermotoga maritima H74A mutant

Analyse Crystal structure of octaprenyl pyrophosphate synthase from hyperthermophilic… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1WL1
Type: protein
Length: 560 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Octoprenyl-diphosphate synthase
EC: 2.5.1.11
UniProt: Q9X1M1
Pockets: 8 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 74% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Octoprenyl-diphosphate synthase (EC 2.5.1.11)	protein	280	74% helix, 1% strand	Q9X1M1

Pockets

8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	727	0.77	0.81	69	empty
2	572	0.76	0.83	64	empty
3	55	0.67	0.96	18	empty
4	260	0.58	0.78	22	empty
5	242	0.57	0.77	20	empty

Interfaces

1 interface between chains.

A–B · 1725 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

1WL1 · Crystal Structure Of Octaprenyl Pyrophosphate Synthase From Hyperthermophilic Thermotoga… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

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Every structure of UniProt Q9X1M1
Elsewhere: RCSB PDB 1WL1 · PDBe 1WL1 · UniProt Q9X1M1

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