Research workbench
TRP RNA-binding attenuation protein in complex with L-tryptophan
Analyse TRP RNA-binding attenuation protein in complex with L-tryptophan in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1WAP
- Type
- protein
- Length
- 1,480 residues
- Chains
- 22
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TRP RNA-binding attenuation protein
- UniProt
- P19466
- Ligands
- TRP
- Pockets
- 20 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 0% helix, 62% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, F, I, M, P, S | TRP RNA-binding attenuation protein | protein | 68 | 0% helix, 62% strand | P19466 |
| B, C, D, E, G, H, J, K, L, N, O, Q, R, T, U, V | TRP RNA-binding attenuation protein | protein | 67 | 0% helix, 63% strand | P19466 |
Ligands and binding sites
- TRP · Tryptophan · ligand · 22 copies · chains A, K, B, C, D, E, F, G, H, I, J, L, V, M, N, O, P, Q, R, S, T, U
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 95 | 0.77 | 0.98 | 21 | TRP |
| 2 | 937 | 0.77 | 0.80 | 83 | empty |
| 3 | 96 | 0.77 | 0.98 | 20 | TRP |
| 4 | 92 | 0.77 | 0.98 | 21 | TRP |
| 5 | 91 | 0.77 | 0.98 | 22 | TRP |
Interfaces
69 interfaces between chains.
- M–N · 1193 Ų buried · 19 hydrogen bonds · protein-protein
- S–T · 1147 Ų buried · 18 hydrogen bonds · protein-protein
- U–V · 1138 Ų buried · 15 hydrogen bonds · protein-protein
- I–J · 1130 Ų buried · 14 hydrogen bonds · protein-protein
- L–M · 1121 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 1WAP · TRP RNA-binding attenuation protein in complex with L-tryptophan · the same entry in another collection · chain J against J, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19466
- Elsewhere: RCSB PDB 1WAP · PDBe 1WAP · UniProt P19466
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