Research workbench
Crystal structure of human kynurenine aminotransferase I in complex with L-phe
Analyse Crystal structure of human kynurenine aminotransferase I in complex with L-phe in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1W7M
- Type
- protein
- Length
- 415 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kynurenine--oxoglutarate transaminase I
- EC
- 4.4.1.13
- UniProt
- Q16773
- Ligands
- PHE, PLP
- Pockets
- 3 · best druggability 0.59
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Kynurenine--oxoglutarate transaminase I (EC 4.4.1.13) | protein | 415 | 46% helix, 15% strand | Q16773 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 222 | 0.59 | 0.80 | 31 | PHE, PLP |
| 2 | 198 | 0.50 | 0.76 | 22 | empty |
| 3 | 153 | 0.45 | 0.75 | 24 | empty |
Modifications
Observed in the structure: 1 cofactor (pyridoxal phosphate Schiff base).
Compared structures
- 1W7M · Crystal structure of human kynurenine aminotransferase I in complex with L-Phe · the same entry in another collection · chain A against A, TM-score 1.00
- Q16773 · AlphaFold monomer V2.0 prediction for kynurenine--oxoglutarate transaminase 1 (Q16773) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q16773
- Elsewhere: RCSB PDB 1W7M · PDBe 1W7M · UniProt Q16773
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