Research workbench
P4 protein from bacteriophage PHI12 apo state
Analyse P4 protein from bacteriophage PHI12 apo state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1W4C
- Type
- protein
- Length
- 7,184 residues
- Chains
- 24
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NTPase P4
- UniProt
- Q94M05
- Pockets
- 20 · best druggability 0.86
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D, H, I, L, U, X | NTPase P4 | protein | 288 | 30% helix, 31% strand | Q94M05 |
| B, C, E, F, G, J, K, M, N, O, P, Q, R, S, T, V, W | NTPase P4 | protein | 304 | 30% helix, 31% strand | Q94M05 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 968 | 0.86 | 0.88 | 118 | empty |
| 2 | 1056 | 0.84 | 0.85 | 128 | empty |
| 3 | 1041 | 0.84 | 0.85 | 130 | empty |
| 4 | 780 | 0.83 | 0.86 | 103 | empty |
| 5 | 582 | 0.82 | 0.88 | 80 | empty |
Interfaces
46 interfaces between chains.
- N–O · 1931 Ų buried · 29 hydrogen bonds · protein-protein
- K–L · 1931 Ų buried · 28 hydrogen bonds · protein-protein
- T–U · 1930 Ų buried · 28 hydrogen bonds · protein-protein
- W–X · 1927 Ų buried · 27 hydrogen bonds · protein-protein
- A–F · 1912 Ų buried · 26 hydrogen bonds · protein-protein
Compared structures
- 1W4C · P4 protein from Bacteriophage PHI12 apo state · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q94M05
- Elsewhere: RCSB PDB 1W4C · PDBe 1W4C · UniProt Q94M05
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