Research workbench
Trigger factor ribosome binding domain in complex with 50S
Analyse Trigger factor ribosome binding domain in complex with 50S in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1W2B
- Type
- protein + RNA
- Length
- 6,615 residues
- Chains
- 31
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 23S rRNA; 50S ribosomal protein L39E; 50S ribosomal protein L44E la, HLA, ribosomal…
- UniProt
- P22452, P32411, P20276, P20279, P12735, P14124, P14135, P12743, P15825, P60617, P29198, P22450, P12737, P60618, P14123, P12733, P14119, P12734, P10970, P12732, P10972, P14116, P10971, P14121, P18138, P12736, P60619, P32410
- Ligands
- MG, NA, CD, K, CL
- Pockets
- 20 · best druggability 0.90
Structure
x-ray diffraction · 31 distinct chains · 28% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| 0 | 23S rRNA | rna | 2754 | — | — |
| 1 | 50S ribosomal protein L39E | protein | 46 | 41% helix, 0% strand | P22452 |
| 2 | 50S ribosomal protein L44E la, HLA, ribosomal protein L44E | protein | 92 | 10% helix, 28% strand | P32411 |
| 5 | Trigger factor | protein | 35 | 20% helix, 0% strand | — |
| 9 | 5S rRNA | rna | 122 | — | — |
| A | 50S ribosomal protein L2P | protein | 237 | 11% helix, 22% strand | P20276 |
| B | 50S ribosomal protein L3P | protein | 337 | 12% helix, 33% strand | P20279 |
| C | 50S ribosomal protein L4P | protein | 246 | 30% helix, 11% strand | P12735 |
| D | 50S ribosomal protein L5P HMAL5, HL13, ribosomal protein L5 | protein | 140 | 26% helix, 19% strand | P14124 |
| E | 50S ribosomal protein L6P | protein | 172 | 23% helix, 38% strand | P14135 |
| F | 50S ribosomal protein L7AE | protein | 119 | 47% helix, 13% strand | P12743 |
| G | 50S ribosomal protein L10E | protein | 29 | 83% helix, 0% strand | P15825 |
| H | 50S ribosomal protein L10E | protein | 156 | 14% helix, 28% strand | P60617 |
| I | 50S ribosomal protein L13P | protein | 142 | 39% helix, 15% strand | P29198 |
| J | 50S ribosomal protein L14P | protein | 132 | 6% helix, 38% strand | P22450 |
| K | 50S ribosomal protein L15P | protein | 145 | 19% helix, 16% strand | P12737 |
| L | 50S ribosomal protein L15E | protein | 194 | 34% helix, 15% strand | P60618 |
| M | 50S ribosomal protein L18P | protein | 186 | 38% helix, 13% strand | P14123 |
| N | 50S ribosomal protein L18E | protein | 115 | 43% helix, 23% strand | P12733 |
| O | 50S ribosomal protein L19E | protein | 143 | 57% helix, 4% strand | P14119 |
| P | 50S ribosomal protein L21E | protein | 95 | 11% helix, 29% strand | P12734 |
| Q | 50S ribosomal protein L22P HMAL22, HL23, ribosomal protein L22 | protein | 150 | 34% helix, 33% strand | P10970 |
| R | 50S ribosomal protein L23P | protein | 84 | 32% helix, 30% strand | P12732 |
| S | Ribosomal protein L24 | protein | 119 | 29% helix, 29% strand | P10972 |
| T | 50S ribosomal protein L24P | protein | 53 | 8% helix, 19% strand | P14116 |
| U | 50S ribosomal protein L24E | protein | 65 | 74% helix, 0% strand | P10971 |
| V | 50S ribosomal protein L30P | protein | 154 | 38% helix, 14% strand | P14121 |
| W | 50S ribosomal protein L31E | protein | 82 | 35% helix, 27% strand | P18138 |
| X | 50S ribosomal protein L32E | protein | 142 | 23% helix, 12% strand | P12736 |
| Y | 50S ribosomal protein L37AE | protein | 73 | 30% helix, 18% strand | P60619 |
| Z | Ribosomal protein L37E | protein | 56 | 7% helix, 11% strand | P32410 |
Ligands and binding sites
- MG · Magnesium ion · metal · 117 copies · chains 0, A, C, R, Q, P, V, 1, Z, X, O, I, L, 2, 9, Y, B, J, S
- NA · Sodium ion · metal · 86 copies · chains 0, B, 1, K, X, 9, I, L, C, 2, H, Q, D, A, P, R, S
- CD · Cadmium ion · metal · 5 copies · chains 2, N, T, Y, Z
- K · Potassium ion · metal · 2 copies · chains 0, L
- CL · Chloride ion · ion · 22 copies · chains 0, 1, I, X, V, 2, A, B, E, J, K, L, D, M, N, P, Q
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1025 | 0.90 | 0.92 | 94 | MG, NA |
| 2 | 1123 | 0.87 | 0.89 | 91 | empty |
| 3 | 1200 | 0.87 | 0.88 | 115 | empty |
| 4 | 687 | 0.86 | 0.91 | 89 | MG, CL |
| 5 | 1173 | 0.86 | 0.88 | 96 | MG, NA |
Interfaces
57 interfaces between chains.
- 0–B · 7406 Ų buried · 224 hydrogen bonds · protein-nucleic
- 0–L · 6812 Ų buried · 161 hydrogen bonds · protein-nucleic
- 0–A · 6231 Ų buried · 167 hydrogen bonds · protein-nucleic
- 0–C · 5560 Ų buried · 129 hydrogen bonds · protein-nucleic
- 0–O · 4344 Ų buried · 113 hydrogen bonds · protein-nucleic
Compared structures
- 1W2B · Trigger Factor ribosome binding domain in complex with 50S · the same entry in another collection · chain F against F, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22452
- Every structure of UniProt P32411
- Every structure of UniProt P20276
- Every structure of UniProt P20279
- Every structure of UniProt P12735
- Every structure of UniProt P14124
- Every structure of UniProt P14135
- Every structure of UniProt P12743
- Every structure of UniProt P15825
- Every structure of UniProt P60617
- Every structure of UniProt P29198
- Every structure of UniProt P22450
- Every structure of UniProt P12737
- Every structure of UniProt P60618
- Every structure of UniProt P14123
- Every structure of UniProt P12733
- Every structure of UniProt P14119
- Every structure of UniProt P12734
- Every structure of UniProt P10970
- Every structure of UniProt P12732
- Every structure of UniProt P10972
- Every structure of UniProt P14116
- Every structure of UniProt P10971
- Every structure of UniProt P14121
- Every structure of UniProt P18138
- Every structure of UniProt P12736
- Every structure of UniProt P60619
- Every structure of UniProt P32410
- Elsewhere: RCSB PDB 1W2B · PDBe 1W2B · UniProt P22452 · UniProt P32411 · UniProt P20276 · UniProt P20279 · UniProt P12735 · UniProt P14124 · UniProt P14135 · UniProt P12743 · UniProt P15825 · UniProt P60617 · UniProt P29198 · UniProt P22450 · UniProt P12737 · UniProt P60618 · UniProt P14123 · UniProt P12733 · UniProt P14119 · UniProt P12734 · UniProt P10970 · UniProt P12732 · UniProt P10972 · UniProt P14116 · UniProt P10971 · UniProt P14121 · UniProt P18138 · UniProt P12736 · UniProt P60619 · UniProt P32410
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