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Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins

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PDB: 1W26
Type: protein
Length: 864 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Trigger factor
UniProt: P22257
Pockets: 5 · best druggability 0.35

Structure

x-ray diffraction · 1 distinct chain · 44% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Trigger factor	protein	432	44% helix, 16% strand	P22257

Pockets

5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	88	0.35	0.74	12	empty
2	59	0.35	0.77	15	empty
3	61	0.33	0.76	19	empty
4	77	0.30	0.73	13	empty
5	59	0.26	0.73	14	empty

Interfaces

1 interface between chains.

A–B · 343 Å² buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 22 modified (engineered).

Compared structures

1W26 · Trigger Factor in Complex with the Ribosome forms a Molecular Cradle for Nascent Proteins · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22257
Elsewhere: RCSB PDB 1W26 · PDBe 1W26 · UniProt P22257

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