Research workbench
Sc SMC1HD:SCC1-C complex, atpgs
Analyse Sc SMC1HD:SCC1-C complex, atpgs in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1W1W
- Type
- protein
- Length
- 1,535 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Structural maintenance of chromosome 1; Sister chromatid cohesion protein 1
- UniProt
- P32908, Q12158
- Ligands
- AGS, MG
- Pockets
- 20 · best druggability 0.80
Structure
x-ray diffraction · 3 distinct chains · 36% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Structural maintenance of chromosome 1 | protein | 274 | 32% helix, 30% strand | P32908 |
| B, C, D | Structural maintenance of chromosome 1 | protein | 327 | 35% helix, 26% strand | P32908 |
| E, F, G, H | Sister chromatid cohesion protein 1 | protein | 70 | 53% helix, 17% strand | Q12158 |
Ligands and binding sites
- AGS · Phosphothiophosphoric acid-adenylate ester · ligand · 4 copies · chains A, B, C, D
- MG · Magnesium ion · metal · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1106 | 0.80 | 0.81 | 122 | MG, AGS |
| 2 | 871 | 0.77 | 0.80 | 98 | MG, AGS |
| 3 | 393 | 0.77 | 0.86 | 42 | empty |
| 4 | 396 | 0.75 | 0.85 | 39 | empty |
| 5 | 168 | 0.71 | 0.89 | 22 | empty |
Interfaces
13 interfaces between chains.
- C–G · 1117 Ų buried · 11 hydrogen bonds · protein-protein
- A–E · 1105 Ų buried · 10 hydrogen bonds · protein-protein
- B–F · 1104 Ų buried · 10 hydrogen bonds · protein-protein
- D–H · 1102 Ų buried · 10 hydrogen bonds · protein-protein
- C–D · 1059 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 1W1W · Sc Smc1hd:Scc1-C complex, ATPgS · the same entry in another collection · chain H against H, TM-score 1.00
- P32908 · AlphaFold monomer V2.0 prediction for structural maintenance of chromosomes protein 1… · a predicted model of the same protein · chain B against A, TM-score 0.98
- Q12158 · AlphaFold monomer V2.0 prediction for sister chromatid cohesion protein 1 (Q12158) · a predicted model of the same protein · chain E against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32908
- Every structure of UniProt Q12158
- Elsewhere: RCSB PDB 1W1W · PDBe 1W1W · UniProt P32908 · UniProt Q12158
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.