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Ornithine acetyltransferase (ORF6 gene product - clavulanic acid biosynthesis) from streptomyces clavuligerus

Analyse Ornithine acetyltransferase (ORF6 gene product - clavulanic acid biosynthesis)… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1VZ6
Type: protein
Length: 752 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ornithine acetyl-transferase
EC: 2.3.1.35
UniProt: Q53940
Ligands: SO4
Pockets: 5 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Ornithine acetyl-transferase (EC 2.3.1.35)	protein	376	35% helix, 28% strand	Q53940

Ligands and binding sites

SO4 · Sulfate ion · ion · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	771	0.72	0.78	61	empty
2	187	0.58	0.81	25	SO4
3	187	0.56	0.80	24	SO4
4	108	0.40	0.76	25	empty
5	89	0.35	0.75	21	empty

Interfaces

1 interface between chains.

A–B · 2105 Å² buried · 31 hydrogen bonds · protein-protein

Compared structures

1VZ6 · Ornithine Acetyltransferase (ORF6 Gene Product - Clavulanic Acid Biosynthesis) from… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q53940
Elsewhere: RCSB PDB 1VZ6 · PDBe 1VZ6 · UniProt Q53940

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