Research workbench
Crystal structure of murine class I MHC H2-db complexed with a synthetic peptide P1027
Analyse Crystal structure of murine class I MHC H2-db complexed with a synthetic… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1BZ9
- Type
- protein
- Length
- 382 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (class I histocompatibility antigen); Protein (peptide P1027 (fapgvfpym))
- UniProt
- P01899, P01887
- Pockets
- 3 · best druggability 0.62
Structure
x-ray diffraction · 3 distinct chains · 19% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (class I histocompatibility antigen) | protein | 273 | 26% helix, 38% strand | P01899 |
| B | Protein (class I histocompatibility antigen) | protein | 100 | 0% helix, 49% strand | P01887 |
| C | Protein (peptide P1027 (fapgvfpym)) | protein | 9 | 0% helix, 0% strand | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 510 | 0.62 | 0.75 | 45 | empty |
| 2 | 145 | 0.47 | 0.77 | 31 | empty |
| 3 | 86 | 0.39 | 0.78 | 18 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1292 Ų buried · 20 hydrogen bonds · protein-protein
- A–C · 863 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 1BZ9 · Crystal structure of murine class I MHC H2-db complexed with a synthetic peptide P1027 · the same entry in another collection · chain A against A, TM-score 1.00
- P01887 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (P01887) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01899
- Every structure of UniProt P01887
- Elsewhere: RCSB PDB 1BZ9 · PDBe 1BZ9 · UniProt P01899 · UniProt P01887
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