Research workbench
Crystal structure of hydroperoxide resistance protein osmc (TM0919) from thermotoga maritima at 1.80 a resolution
Analyse Crystal structure of hydroperoxide resistance protein osmc (TM0919) from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1VLA
- Type
- protein
- Length
- 563 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hydroperoxide resistance protein osmc
- UniProt
- Q9X021
- Pockets
- 7 · best druggability 0.88
Structure
x-ray diffraction · 4 distinct chains · 31% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hydroperoxide resistance protein osmc | protein | 144 | 30% helix, 35% strand | Q9X021 |
| B | Hydroperoxide resistance protein osmc | protein | 142 | 30% helix, 35% strand | Q9X021 |
| C | Hydroperoxide resistance protein osmc | protein | 140 | 31% helix, 33% strand | Q9X021 |
| D | Hydroperoxide resistance protein osmc | protein | 137 | 31% helix, 34% strand | Q9X021 |
Pockets
7 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 310 | 0.88 | 0.98 | 30 | empty |
| 2 | 354 | 0.61 | 0.77 | 32 | empty |
| 3 | 352 | 0.59 | 0.76 | 32 | empty |
| 4 | 290 | 0.58 | 0.77 | 33 | empty |
| 5 | 195 | 0.50 | 0.76 | 25 | empty |
Interfaces
6 interfaces between chains.
- A–B · 3074 Ų buried · 42 hydrogen bonds · protein-protein
- C–D · 2793 Ų buried · 33 hydrogen bonds · protein-protein
- A–D · 429 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 424 Ų buried · 3 hydrogen bonds · protein-protein
- A–C · 219 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 32 modified (engineered).
Compared structures
- 1VLA · Crystal structure of Hydroperoxide resistance protein OsmC (TM0919) from Thermotoga… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9X021
- Elsewhere: RCSB PDB 1VLA · PDBe 1VLA · UniProt Q9X021
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