Research workbench
The major NAD(P)H:FMN oxidoreductase from vibrio fischeri
Analyse The major NAD(P)H:FMN oxidoreductase from vibrio fischeri in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1VFR
- Type
- protein
- Length
- 434 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NAD(P)H\:FMN oxidoreductase
- EC
- 1.6.99.-
- UniProt
- P46072
- Ligands
- FMN
- Pockets
- 3 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 49% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | NAD(P)H\:FMN oxidoreductase (EC 1.6.99.-) | protein | 217 | 49% helix, 16% strand | P46072 |
Ligands and binding sites
- FMN · Flavin mononucleotide · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 464 | 0.75 | 0.84 | 45 | FMN |
| 2 | 480 | 0.75 | 0.84 | 47 | FMN |
| 3 | 327 | 0.57 | 0.76 | 41 | empty |
Interfaces
1 interface between chains.
- A–B · 3545 Ų buried · 58 hydrogen bonds · protein-protein
Compared structures
- 1VFR · The major NAD(P)H:FMN oxidoreductase from vibrio fischeri · the same entry in another collection · chain A against A, TM-score 1.00
- P46072 · AlphaFold monomer V2.0 prediction for major NAD(P)H-flavin oxidoreductase (P46072) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P46072
- Elsewhere: RCSB PDB 1VFR · PDBe 1VFR · UniProt P46072
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