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Crystal structure of fumarase from thermus thermophilus HB8

Analyse Crystal structure of fumarase from thermus thermophilus HB8 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1VDK
Type: protein
Length: 915 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fumarate hydratase class II
EC: 4.2.1.2
UniProt: P84127
Pockets: 5 · best druggability 0.66

Structure

x-ray diffraction · 2 distinct chains · 61% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fumarate hydratase class II (EC 4.2.1.2)	protein	458	60% helix, 7% strand	P84127
B	Fumarate hydratase class II (EC 4.2.1.2)	protein	457	61% helix, 7% strand	P84127

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	403	0.66	0.79	53	empty
2	320	0.58	0.76	44	empty
3	86	0.35	0.75	22	empty
4	85	0.34	0.74	20	empty
5	53	0.27	0.74	13	empty

Interfaces

1 interface between chains.

A–B · 1598 Å² buried · 24 hydrogen bonds · protein-protein

Compared structures

1VDK · Crystal structure of fumarase from thermus thermophilus HB8 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P84127
Elsewhere: RCSB PDB 1VDK · PDBe 1VDK · UniProt P84127

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