Research workbench

The crystal structure of human procathepsin K

Analyse The crystal structure of human procathepsin K in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1BY8
Type: protein
Length: 310 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (procathepsin K)
EC: 3.4.22.38
UniProt: P43235
Pockets: 3 · best druggability 0.43

Structure

x-ray diffraction · 1 distinct chain · 33% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein (procathepsin K) (EC 3.4.22.38)	protein	310	33% helix, 16% strand	P43235

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	84	0.43	0.80	21	empty
2	56	0.39	0.80	15	empty
3	111	0.36	0.74	15	empty

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

1BY8 · The crystal structure of human procathepsin K · the same entry in another collection · chain A against A, TM-score 1.00
P43235 · AlphaFold monomer V2.0 prediction for cathepsin K (P43235) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P43235
Elsewhere: RCSB PDB 1BY8 · PDBe 1BY8 · UniProt P43235

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.