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Crystal structure of anthranilate phosphoribosyltransferase (trpd) from thermus thermophilus HB8

Analyse Crystal structure of anthranilate phosphoribosyltransferase (trpd) from thermus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1V8G
Type: protein
Length: 658 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Anthranilate phosphoribosyltransferase
EC: 2.4.2.18
UniProt: P83827
Pockets: 4 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 53% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Anthranilate phosphoribosyltransferase (EC 2.4.2.18)	protein	329	53% helix, 13% strand	P83827

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	652	0.75	0.81	57	empty
2	621	0.74	0.81	57	empty
3	56	0.33	0.77	14	empty
4	58	0.33	0.77	14	empty

Interfaces

1 interface between chains.

A–B · 763 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

1V8G · Crystal structure of anthranilate phosphoribosyltransferase (TrpD) from Thermus… · the same entry in another collection · chain B against B, TM-score 1.00
P83827 · AlphaFold monomer V2.0 prediction for anthranilate phosphoribosyltransferase (P83827) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P83827
Elsewhere: RCSB PDB 1V8G · PDBe 1V8G · UniProt P83827

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