Research workbench
Structure of 3-isopropylmalate isomerase small subunit from pyrococcus horikoshii
Analyse Structure of 3-isopropylmalate isomerase small subunit from pyrococcus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1V7L
- Type
- protein
- Length
- 325 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 3-isopropylmalate dehydratase small subunit
- EC
- 4.2.1.33
- UniProt
- O59393
- Pockets
- 2 · best druggability 0.43
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) | protein | 162 | 30% helix, 23% strand | O59393 |
| B | 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) | protein | 163 | 31% helix, 22% strand | O59393 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 131 | 0.43 | 0.76 | 32 | empty |
| 2 | 71 | 0.32 | 0.75 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 501 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 1V7L · Structure of 3-isopropylmalate isomerase small subunit from Pyrococcus horikoshii · the same entry in another collection · chain A against A, TM-score 1.00
- O59393 · AlphaFold monomer V2.0 prediction for 3-isopropylmalate dehydratase small subunit (O59393) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O59393
- Elsewhere: RCSB PDB 1V7L · PDBe 1V7L · UniProt O59393
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.