Research workbench
Structure of human prl-3, the phosphatase associated with cancer metastasis
Analyse Structure of human prl-3, the phosphatase associated with cancer metastasis in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1V3A
- Type
- protein
- Length
- 162 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein tyrosine phosphatase type iva
- EC
- 3.1.3.48
- UniProt
- O75365
- Pockets
- 3 · best druggability 0.58
Structure
solution nmr · 1 distinct chain · 33% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein tyrosine phosphatase type iva (EC 3.1.3.48) | protein | 162 | 33% helix, 12% strand | O75365 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 203 | 0.58 | 0.80 | 42 | empty |
| 2 | 88 | 0.51 | 0.83 | 17 | empty |
| 3 | 102 | 0.45 | 0.79 | 23 | empty |
Compared structures
- 1V3A · Structure of human PRL-3, the phosphatase associated with cancer metastasis · the same entry in another collection · chain A against A, TM-score 1.00
- O75365 · AlphaFold monomer V2.0 prediction for protein tyrosine phosphatase type iva 3 (O75365) · a predicted model of the same protein · chain A against A, TM-score 0.73
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75365
- Elsewhere: RCSB PDB 1V3A · PDBe 1V3A · UniProt O75365
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